Mutations in RHOT1 Disrupt Endoplasmic Reticulum–Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease

Aims: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial shape transition, which is a prerequisite for the initiation of mitophagy. Moreover, altered Miro1 p...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Grossmann, Dajana, Berenguer-Escuder, Clara, Bellet, Marie Estelle, Scheibner, David, Bohler, Jill, Massart, Francois, Rapaport, Doron, Skupin, Alexander, Fouquier d'Hérouël, Aymeric, Sharma, Manu, Ghelfi, Jenny, Raković, Aleksandar, Lichtner, Peter, Antony, Paul, Glaab, Enrico, May, Patrick, Dimmer, Kai Stefan, Fitzgerald, Julia Catherine, Grünewald, Anne, Krüger, Rejko
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798875/
https://ncbi.nlm.nih.gov/pubmed/31303019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2018.7718
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