Mutations in RHOT1 Disrupt Endoplasmic Reticulum–Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease

Aims: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial shape transition, which is a prerequisite for the initiation of mitophagy. Moreover, altered Miro1 p...

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Bibliographic Details
Published in:Antioxid Redox Signal
Main Authors: Grossmann, Dajana, Berenguer-Escuder, Clara, Bellet, Marie Estelle, Scheibner, David, Bohler, Jill, Massart, Francois, Rapaport, Doron, Skupin, Alexander, Fouquier d'Hérouël, Aymeric, Sharma, Manu, Ghelfi, Jenny, Raković, Aleksandar, Lichtner, Peter, Antony, Paul, Glaab, Enrico, May, Patrick, Dimmer, Kai Stefan, Fitzgerald, Julia Catherine, Grünewald, Anne, Krüger, Rejko
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc., publishers 2019
Subjects:
Original Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798875/
https://ncbi.nlm.nih.gov/pubmed/31303019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2018.7718
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