Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation

Immune checkpoint inhibitor (ICI) use remains a challenge in patients with solid organ allografts as most would undergo rejection. In a melanoma patient in whom programmed-death 1 (PD-1) blockade resulted in organ rejection and colitis, the addition of the mTOR inhibitor sirolimus resulted in ongoin...

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Udgivet i:Nat Commun
Main Authors: Esfahani, Khashayar, Al-Aubodah, Tho-Alfakar, Thebault, Pamela, Lapointe, Réjean, Hudson, Marie, Johnson, Nathalie A., Baran, Dana, Bhulaiga, Najwa, Takano, Tomoko, Cailhier, Jean-François, Piccirillo, Ciriaco A., Miller, Wilson H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797722/
https://ncbi.nlm.nih.gov/pubmed/31624262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12628-1
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