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Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation
Immune checkpoint inhibitor (ICI) use remains a challenge in patients with solid organ allografts as most would undergo rejection. In a melanoma patient in whom programmed-death 1 (PD-1) blockade resulted in organ rejection and colitis, the addition of the mTOR inhibitor sirolimus resulted in ongoin...
में बचाया:
| में प्रकाशित: | Nat Commun |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6797722/ https://ncbi.nlm.nih.gov/pubmed/31624262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12628-1 |
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