Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-κB

Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseas...

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Bibliografiske detaljer
Main Authors: Costa, Lara F., Balcells, Mercedes, Edelman, Elazer R., Nadler, Lee M., Cardoso, Angelo A.
Format: Artigo
Sprog:Inglês
Udgivet: © 2006 by The American Society of Hematology 2006
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895363/
https://ncbi.nlm.nih.gov/pubmed/16141350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2208
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