Mouse Model of Thyroid Cancer Progression and Dedifferentiation Driven by STRN-ALK Expression and Loss of p53: Evidence for the Existence of Two Types of Poorly Differentiated Carcinoma

Background: Thyroid tumor progression from well-differentiated cancer to poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) involves step-wise dedifferentiation associated with loss of iodine avidity and poor outcomes. ALK fusions, typically STRN-ALK, are found wit...

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Udgivet i:Thyroid
Main Authors: Nikitski, Alyaksandr V., Rominski, Susan L., Condello, Vincenzo, Kaya, Cihan, Wankhede, Mamta, Panebianco, Federica, Yang, Hong, Altschuler, Daniel L., Nikiforov, Yuri E.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2019
Fag:
Thyroid Cancer and Nodules
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797076/
https://ncbi.nlm.nih.gov/pubmed/31298630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0284
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