Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer

Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anapl...

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Detalhes bibliográficos
Main Authors: Kelly, Lindsey M., Barila, Guillermo, Liu, Pengyuan, Evdokimova, Viktoria N., Trivedi, Sumita, Panebianco, Federica, Gandhi, Manoj, Carty, Sally E., Hodak, Steven P., Luo, Jianhua, Dacic, Sanja, Yu, Yan P., Nikiforova, Marina N., Ferris, Robert L., Altschuler, Daniel L., Nikiforov, Yuri E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964116/
https://ncbi.nlm.nih.gov/pubmed/24613930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321937111
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