ALK FISH patterns and the detection of ALK fusions by next generation sequencing in lung adenocarcinoma

Break-apart ALK FISH probe is the FDA approved approach for detection of ALK rearrangements in lung carcinoma patients who may benefit from ALK kinase inhibitors. The FISH assay can be technically challenging and difficult to interpret. ALK immunohistochemistry and next generation sequencing have be...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Dacic, Sanja, Villaruz, Liza C., Abberbock, Shira, Mahaffey, Alyssa, Incharoen, Pimpin, Nikiforova, Marina N.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347743/
https://ncbi.nlm.nih.gov/pubmed/27769042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12705
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