Characterization of Activating Mutations of the MEK1 Gene in Papillary Thyroid Carcinomas

Background: Genetic alterations activating the mitogen-activated protein kinase (MAPK) signaling pathway, most commonly BRAF and RAS mutations, are common in papillary thyroid carcinoma (PTC). Somatic mutations of the MEK gene, also known as mitogen-activated protein kinase kinase 1 (MAP2K1), coding...

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Detalhes bibliográficos
Publicado no:Thyroid
Main Authors: Borrelli, Nicla, Panebianco, Federica, Condello, Vincenzo, Barletta, Justine A., Kaya, Cihan, Yip, Linwah, Nikiforova, Marina N., Nikiforov, Yuri E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Thyroid Cancer and Nodules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913803/
https://ncbi.nlm.nih.gov/pubmed/31407636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0065
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