NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation

Oriented cell divisions are controlled by a conserved molecular cascade involving Gαi, LGN, and NuMA. Here, we show that NDP52 regulates spindle orientation via remodeling the polar cortical actin cytoskeleton. siRNA-mediated NDP52 suppression surprisingly revealed a ring-like compact subcortical F-...

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Pubblicato in:Cell Res
Autori principali: Yu, Huijuan, Yang, Fengrui, Dong, Peng, Liao, Shanhui, Liu, Wei R., Zhao, Gangyin, Qin, Bo, Dou, Zhen, Liu, Zhe, Liu, Wei, Zang, Jianye, Lippincott-Schwartz, Jennifer, Liu, Xing, Yao, Xuebiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796859/
https://ncbi.nlm.nih.gov/pubmed/31201383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0189-9
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