Transgenic Expression of Intraneuronal Aβ(42) But Not Aβ(40) Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

An early role of amyloid-β peptide (Aβ) aggregation in Alzheimer's disease pathogenesis is well established. However, the contribution of intracellular or extracellular forms of Aβ to the neurodegenerative process is a subject of considerable debate. We here describe transgenic mice expressing...

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Publicado no:J Neurosci
Main Authors: Abramowski, Dorothee, Rabe, Sabine, Upadhaya, Ajeet Rijal, Reichwald, Julia, Danner, Simone, Staab, Dieter, Capetillo-Zarate, Estibaliz, Yamaguchi, Haruyasu, Saido, Takaomi C., Wiederhold, Karl-Heinz, Thal, Dietmar Rudolf, Staufenbiel, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796269/
https://ncbi.nlm.nih.gov/pubmed/22279212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4586-11.2012
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