Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice

INTRODUCTION: The deposition of the amyloid β protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Removal of Aβ by Aβ-antibody treatment has been developed as a potential treatment strategy against AD. First clinical trials showed neither a stop nor a reduction of disease progr...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Balakrishnan, Karthikeyan, Rijal Upadhaya, Ajeet, Steinmetz, Julia, Reichwald, Julia, Abramowski, Dorothee, Fändrich, Marcus, Kumar, Sathish, Yamaguchi, Haruyasu, Walter, Jochen, Staufenbiel, Matthias, Thal, Dietmar Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491274/
https://ncbi.nlm.nih.gov/pubmed/26141728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0217-z
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