P11.31 EB1-dependent survival of glioblastoma tumor-bearing mice after treatment with the novel checkpoint activator BAL101553 is associated with inhibition of cancer stem-like cell-mediated tumor angiogenesis and astrocytic differentiation

BACKGROUND: Glioblastoma (GBM) patients have limited treatment options. Cancer stem-like cells (CSLCs) contribute to GBM invasiveness, representing promising targets. BAL101553 is a novel small molecule tubulin-binding agent, promoting tumor cell death through spindle assembly checkpoint activation,...

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Vydáno v:Neuro Oncol
Hlavní autoři: Berges, R, Tchoghandjian, A, Serge, A, Honore, S, Figarella-Branger, D, Bachmann, F, Lane, H, Braguer, D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Poster Presentations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796132/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.177
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