Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis (EGE). Current treatment options, such as diet restrict...

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Vydáno v:JCI Insight
Hlavní autoři: Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bochner, Bruce S., Rasmussen, Henrik S., Peterson, Kathryn, Bebbington, Christopher, Tomasevic, Nenad
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795394/
https://ncbi.nlm.nih.gov/pubmed/31465299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126219
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