AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

INTRODUCTION: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basoph...

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Udgivet i:Int Arch Allergy Immunol
Main Authors: Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bryce, Paul J., Bright, Jessica, Williams, Jason, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A., Bebbington, Christopher, Tomasevic, Nenad
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2019
Fag:
Experimental Allergy - Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878738/
https://ncbi.nlm.nih.gov/pubmed/31401630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000501637
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