Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis (EGE). Current treatment options, such as diet restrict...

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Udgivet i:JCI Insight
Main Authors: Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bochner, Bruce S., Rasmussen, Henrik S., Peterson, Kathryn, Bebbington, Christopher, Tomasevic, Nenad
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795394/
https://ncbi.nlm.nih.gov/pubmed/31465299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126219
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