Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis (EGE). Current treatment options, such as diet restrict...

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Опубликовано в: :JCI Insight
Главные авторы: Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bochner, Bruce S., Rasmussen, Henrik S., Peterson, Kathryn, Bebbington, Christopher, Tomasevic, Nenad
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795394/
https://ncbi.nlm.nih.gov/pubmed/31465299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126219
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