Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes

Thyroid hormone (TH) signaling is a universal regulator of metabolism, growth, and development. Here, we show that TH-TH receptor (TH-TR) axis alterations are critically involved in diabetic nephropathy–associated (DN-associated) podocyte pathology, and we identify TRα1 as a key regulator of the pat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Benedetti, Valentina, Lavecchia, Angelo Michele, Locatelli, Monica, Brizi, Valerio, Corna, Daniela, Todeschini, Marta, Novelli, Rubina, Benigni, Ariela, Zoja, Carlamaria, Remuzzi, Giuseppe, Xinaris, Christodoulos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795387/
https://ncbi.nlm.nih.gov/pubmed/31534055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130249
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