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α(1)F64 Residue at GABA(A) Receptor Binding Site Is Involved in Gating by Influencing the Receptor Flipping Transitions
GABA receptors (GABA(A)Rs) mediate inhibition in the adult brain. These channels are heteropentamers and their ligand binding sites are localized at the β(+)/α(−) interfaces. As expected, mutations of binding-site residues affect binding kinetics but accumulating evidence indicates that gating is al...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6795308/ https://ncbi.nlm.nih.gov/pubmed/24573278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2533-13.2014 |
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