Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA(A) Receptor Activity

GABA(A) receptors (GABA(A)Rs) play a crucial inhibitory role in the CNS. Benzodiazepines (BDZs) are positive modulators of specific subtypes of GABA(A)Rs, but the underlying mechanism remains obscure. Early studies demonstrated the major impact of BDZs on binding and more recent investigations indic...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Jatczak-Śliwa, Magdalena, Terejko, Katarzyna, Brodzki, Marek, Michałowski, Michał A., Czyzewska, Marta M., Nowicka, Joanna M., Andrzejczak, Anna, Srinivasan, Rakenduvadhana, Mozrzymas, Jerzy W.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121034/
https://ncbi.nlm.nih.gov/pubmed/30210295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00237
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