CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence

Chronic morphine administration increases levels of adenylyl cyclase and cAMP-dependent protein kinase (PKA) activity in the locus coeruleus (LC), which contributes to the severalfold activation of LC neurons that occurs during opiate withdrawal. A role for the transcription factor cAMP response ele...

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Publicado en:J Neurosci
Main Authors: Lane-Ladd, Sarah B., Pineda, Joseba, Boundy, Virginia A., Pfeuffer, T., Krupinski, John, Aghajanian, George K., Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 1997
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793917/
https://ncbi.nlm.nih.gov/pubmed/9315909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-20-07890.1997
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