p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

The tumor suppressor gene p53 has been implicated in the induction of apoptosis in dividing cells. We now show that overexpression of p53 using an adenoviral vector in cultured rat hippocampal pyramidal neurons causes widespread neuronal death with features typical of apoptosis. p53 overexpression d...

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發表在:J Neurosci
Main Authors: Jordán, Joaquín, Galindo, María F., Prehn, Jochen H. M., Weichselbaum, Ralph R., Beckett, Michael, Ghadge, Ghanashyam D., Roos, Raymond P., Leiden, Jeffrey M., Miller, Richard J.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 1997
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793734/
https://ncbi.nlm.nih.gov/pubmed/9006981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-04-01397.1997
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