p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

The tumor suppressor gene p53 has been implicated in the induction of apoptosis in dividing cells. We now show that overexpression of p53 using an adenoviral vector in cultured rat hippocampal pyramidal neurons causes widespread neuronal death with features typical of apoptosis. p53 overexpression d...

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Publicado en:J Neurosci
Autores principales: Jordán, Joaquín, Galindo, María F., Prehn, Jochen H. M., Weichselbaum, Ralph R., Beckett, Michael, Ghadge, Ghanashyam D., Roos, Raymond P., Leiden, Jeffrey M., Miller, Richard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 1997
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793734/
https://ncbi.nlm.nih.gov/pubmed/9006981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-04-01397.1997
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