Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway

BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer which is associated with poor patient outcome and lack of targeted therapy. Our laboratory has synthesized a series of indole-2-carboxamide derivatives. Among this series, compound LG25 showed a favorable phar...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Xu, Xiaohong, Rajamanickam, Vinothkumar, Shu, Sheng, Liu, Zhoudi, Yan, Tao, He, Jinxin, Liu, Zhiguo, Guo, Guilong, Liang, Guang, Wang, Yi
Format: Artigo
Language:Inglês
Published: Dove 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793079/
https://ncbi.nlm.nih.gov/pubmed/31631978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S216542
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