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Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of NLRP3 Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway

BACKGROUND: Type 2 diabetes impairs the healing process and induces apoptosis of fibroblasts, which are thought to be involved in this process. We investigated the possible mechanisms involved in AGEs-induced apoptosis of human dermal fibroblasts. MATERIAL/METHODS: We examined the expression of apop...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Dai, Jiezhi, Chen, Hua, Chai, Yimin
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792499/
https://ncbi.nlm.nih.gov/pubmed/31587010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915806
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