Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Anthracyclines-induced cardiotoxicity has become one of the major restrictions of their clinical applications. Klotho showed cardioprotective effects. This study aimed to investigate the effects and possible mechanisms of klotho on doxorubicin (DOX)-induced cardiotoxicity. MATERIAL/METHO...

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Vydáno v:Med Sci Monit
Hlavní autoři: Zhu, Huolan, Gao, Yan, Zhu, Shunming, Cui, Qianwei, Du, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: International Scientific Literature, Inc. 2017
Témata:
Lab/In Vitro Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687120/
https://ncbi.nlm.nih.gov/pubmed/29107939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.907449
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