Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Anthracyclines-induced cardiotoxicity has become one of the major restrictions of their clinical applications. Klotho showed cardioprotective effects. This study aimed to investigate the effects and possible mechanisms of klotho on doxorubicin (DOX)-induced cardiotoxicity. MATERIAL/METHO...

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Bibliografiska uppgifter
I publikationen:Med Sci Monit
Huvudupphovsmän: Zhu, Huolan, Gao, Yan, Zhu, Shunming, Cui, Qianwei, Du, Jie
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Scientific Literature, Inc. 2017
Ämnen:
Lab/In Vitro Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687120/
https://ncbi.nlm.nih.gov/pubmed/29107939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.907449
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