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Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy
Human NK cell anti-tumor activities involve antibody-dependent cell-mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor-targeting therapeutic mAbs. Human NK cells exclusively recognize these antibodies by the Fcγ receptor CD16A (FcγRIIIA), one of...
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| Publicado no: | J Leukoc Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6792391/ https://ncbi.nlm.nih.gov/pubmed/30786043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.2MR1218-501R |
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