Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in expression by ADAM17-mediated proteolytic cleavage upon cell activation by various stimuli. We examined soluble CD16 released from ac...

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Bibliographic Details
Published in:PLoS One
Main Authors: Jing, Yawu, Ni, Zhenya, Wu, Jianming, Higgins, LeeAnn, Markowski, Todd W., Kaufman, Dan S., Walcheck, Bruce
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376770/
https://ncbi.nlm.nih.gov/pubmed/25816339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121788
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