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p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill

Loss of tumor suppression by the p53 protein involves altered or abrogated transcriptional activity resulting in a failure to mediate wild‐type cellular responses including cell cycle arrest, senescence, and apoptosis. Timofeev et al (2019) make the fascinating finding that a novel p53 cooperativity...

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Pubblicato in:EMBO J
Autore principale: Manfredi, James J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792014/
https://ncbi.nlm.nih.gov/pubmed/31553097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103322
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