Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression

E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S‐phase entry and progression. Previously, we demonstrated that these atypical E2Fs are degraded by APC/C(C) (dh1) during G1 phase of the cell cycle. However, the mechanism driving the downregulation of atypic...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Yuan, Ruixue, Liu, Qingwu, Segeren, Hendrika A, Yuniati, Laurensia, Guardavaccaro, Daniele, Lebbink, Robert J, Westendorp, Bart, de Bruin, Alain
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792010/
https://ncbi.nlm.nih.gov/pubmed/31475738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101430
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