Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

BACKGROUND: Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) control energy homeostasis by sensing hormonal and nutrient cues and activating secondary melanocortin sensing neurons. We identified the expression of a G protein-coupled receptor, Gpr17, in the ARH and...

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Gepubliceerd in:Nutr Diabetes
Hoofdauteurs: Reilly, Austin M., Zhou, Shudi, Panigrahi, Sunil K., Yan, Shijun, Conley, Jason M., Sheets, Patrick L., Wardlaw, Sharon L., Ren, Hongxia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791877/
https://ncbi.nlm.nih.gov/pubmed/31611548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41387-019-0096-7
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