The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and concomitant loss of BAF47 subunit assembly. Here we demonstrate that SS18-SSX globally hijacks BAF complexes on chromatin to activate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: McBride, Matthew J., Pulice, John L., Beird, Hannah C., Ingram, Davis R., D’Avino, Andrew R., Shern, Jack F., Charville, Gregory W., Hornick, Jason L., Nakayama, Robert T., Garcia-Rivera, Enrique M., Araujo, Dejka M., Wang, Wei-Lien, Tsai, Jen-Wei, Yeagley, Michelle, Wagner, Andrew J., Futreal, P. Andrew, Khan, Javed, Lazar, Alexander J., Kadoch, Cigall
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791822/
https://ncbi.nlm.nih.gov/pubmed/29861296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.002
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg