The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and concomitant loss of BAF47 subunit assembly. Here we demonstrate that SS18-SSX globally hijacks BAF complexes on chromatin to activate...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: McBride, Matthew J., Pulice, John L., Beird, Hannah C., Ingram, Davis R., D’Avino, Andrew R., Shern, Jack F., Charville, Gregory W., Hornick, Jason L., Nakayama, Robert T., Garcia-Rivera, Enrique M., Araujo, Dejka M., Wang, Wei-Lien, Tsai, Jen-Wei, Yeagley, Michelle, Wagner, Andrew J., Futreal, P. Andrew, Khan, Javed, Lazar, Alexander J., Kadoch, Cigall
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791822/
https://ncbi.nlm.nih.gov/pubmed/29861296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.002
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