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The SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to drive synovial sarcoma
Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal translocation involving genes encoding the SWI-SNF complex component SS18 and a SSX (SSX1 or SSX2) transcriptional repressor. Using functional genomics, we identify KDM2B – a histone demethylase and component of a non-...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881394/ https://ncbi.nlm.nih.gov/pubmed/29502955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.018 |
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