The SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to drive synovial sarcoma

Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal translocation involving genes encoding the SWI-SNF complex component SS18 and a SSX (SSX1 or SSX2) transcriptional repressor. Using functional genomics, we identify KDM2B – a histone demethylase and component of a non-...

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Publicat a:Cancer Cell
Autors principals: Banito, Ana, Li, Xiang, Laporte, Aimée N., Roe, Jae-Seok, Sanchez-Vega, Francisco, Huang, Chun-Hao, Dancsok, Amanda R., Hatzi, Katerina, Chen, Chi-Chao, Tschaharganeh, Darjus F., Chandwani, Rohit, Tasdemir, Nilgun, Jones, Kevin B., Capecchi, Mario R., Vakoc, Christopher R., Schultz, Nikolaus, Ladanyi, Marc, Nielsen, Torsten O., Lowe, Scott W
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881394/
https://ncbi.nlm.nih.gov/pubmed/29502955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.018
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