Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics

Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that the SS18-SSX fusion oncoprotein is both necessary and sufficient to support tumorigenesis; however, its mechanism of actio...

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Detalhes bibliográficos
Main Authors: Su, Le, Sampaio, Arthur V., Jones, Kevin B., Pacheco, Marina, Goytain, Angela, Lin, Shujun, Poulin, Neal, Yi, Lin, Rossi, Fabio M., Kast, Juergen, Capecchi, Mario R., Underhill, T. Michael, Nielsen, Torsten O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734954/
https://ncbi.nlm.nih.gov/pubmed/22439931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.01.010
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