Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8(+) T cell function and survival through elevation of PD-L1

Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells contributes to malignancy through suppression of the T cell-mediated antitumor response. Pyruvate dehydrogenase kinase 1 (PDK1), a...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Wang, Jing-Jing, Siu, Michelle K., Jiang, Yu-Xin, Leung, Thomas H., Chan, David W., Cheng, Ran-Ran, Cheung, Annie N., Ngan, Hextan Y., Chan, Karen K.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791447/
https://ncbi.nlm.nih.gov/pubmed/31646108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1659092
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