PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling

Ovarian cancer is the most lethal gynecological malignancies owing to the lack of definitive symptoms until development of widespread metastases. Identification of novel prognostic and therapeutic targets is therefore an urgent need to improve survival. Here, we demonstrated high expression of the m...

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Vydáno v:Oncogenesis
Hlavní autoři: Siu, Michelle K. Y., Jiang, Yu-xin, Wang, Jing-jing, Leung, Thomas H. Y., Ngu, Siew Fei, Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028730/
https://ncbi.nlm.nih.gov/pubmed/32071289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0209-0
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