Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy. Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism. Here, we demonstrated that HK2 was...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Siu, Michelle K. Y., Jiang, Yu-Xin, Wang, Jing-Jing, Leung, Thomas H. Y., Han, Chae Young, Tsang, Benjamin K., Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627345/
https://ncbi.nlm.nih.gov/pubmed/31212816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060813
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