Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer

BACKGROUND: Ovarian cancer is characterised by frequent recurrence due to persistent presence of residual cancer stem cells (CSCs). Here, we identify and characterise tumour subsets from ascites-derived tumour cells with stemness, metastasis and metabolic switch properties and to delineate the invol...

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Gepubliceerd in:Br J Cancer
Hoofdauteurs: Jiang, Yu-Xin, Siu, Michelle Kwan-Yee, Wang, Jing-Jing, Mo, Xue-Tang, Leung, Thomas Ho-Yin, Chan, David Wai, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374705/
https://ncbi.nlm.nih.gov/pubmed/32390009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0865-z
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