Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity

Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinectedin reinstates and enhances systemic anticancer immune responses. Lurbinectedin treatment showed traits of imm...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Xie, Wei, Forveille, Sabrina, Iribarren, Kristina, Sauvat, Allan, Senovilla, Laura, Wang, Yan, Humeau, Juliette, Perez-Lanzon, Maria, Zhou, Heng, Martínez-Leal, Juan F., Kroemer, Guido, Kepp, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791417/
https://ncbi.nlm.nih.gov/pubmed/31646106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1656502
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