RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade

BACKGROUND: Antibody-mediated targeting of regulatory T cell receptors such as CTLA-4 enhances antitumor immune responses against several cancer entities including malignant melanoma. Yet, therapeutic success in patients remains variable underscoring the need for novel combinatorial approaches. METH...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Heidegger, Simon, Kreppel, Diana, Bscheider, Michael, Stritzke, Florian, Nedelko, Tatiana, Wintges, Alexander, Bek, Sarah, Fischer, Julius C., Graalmann, Theresa, Kalinke, Ulrich, Bassermann, Florian, Haas, Tobias, Poeck, Hendrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444128/
https://ncbi.nlm.nih.gov/pubmed/30852164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.056
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