Type I interferon signaling before hematopoietic stem cell transplantation lowers donor T cell activation via reduced allogenicity of recipient cells

Recent studies highlight immunoregulatory functions of type I interferons (IFN-I) during the pathogenesis of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We demonstrated that selective activation of IFN-I pathways including RIG-I/MAVS and cGA...

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Pubblicato in:Sci Rep
Autori principali: Fischer, Julius C., Bscheider, Michael, Göttert, Sascha, Thiele Orberg, Erik, Combs, Stephanie E., Bassermann, Florian, Heidegger, Simon, Haas, Tobias, Poeck, Hendrik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800427/
https://ncbi.nlm.nih.gov/pubmed/31628411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51431-2
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