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A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure
A p-isothiocyanate phenylalanine mutant of the homodimeric protein homoserine o-succinyltransferase (MetA) was isolated in a temperature dependent selection from a library of metA mutants containing noncanonical amino acids. This mutant protein has a dramatic increase of 24°C in thermal stability co...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791372/ https://ncbi.nlm.nih.gov/pubmed/31181898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00002 |
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