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A general strategy for engineering noncanonical amino acid dependent bacterial growth

Synthetic auxotrophy in which bacterial viability depends on the presence of a synthetic amino acid provides a robust strategy for the containment of genetically modified organisms and the development of safe, live vaccines. However, a simple, general strategy to evolve essential proteins to be depe...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Koh, Minseob, Yao, Anzhi, Gleason, Patrick R., Mills, Jeremy H., Schultz, Peter G.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501724/
https://ncbi.nlm.nih.gov/pubmed/31580059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08491
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