High Effectiveness in Actions of Carfilzomib on Delayed-Rectifier K(+) Current and on Spontaneous Action Potentials

Carfilzomib (CFZ, Kyprolis(®)) is widely recognized as an irreversible inhibitor of proteasome activity; however, its actions on ion currents in electrically excitable cells are largely unresolved. The possible actions of CFZ on ionic currents and membrane potential in pituitary GH(3), A7r5 vascular...

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Опубликовано в: :Front Pharmacol
Главные авторы: So, Edmund Cheung, Liu, Ping-Yen, Lee, Chien-Ching, Wu, Sheng-Nan
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791059/
https://ncbi.nlm.nih.gov/pubmed/31649537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01163
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