Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

Microscopy of Lewy bodies in Parkinson’s disease (PD) suggests they are not solely filamentous deposits of α-synuclein (αS) but also contain vesicles and other membranous material. We previously reported the existence of native αS tetramers/multimers and described engineered mutations of the αS KTKE...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Imberdis, Thibaut, Negri, Joseph, Ramalingam, Nagendran, Terry-Kantor, Elizabeth, Ho, Gary P. H., Fanning, Saranna, Stirtz, Georgia, Kim, Tae-Eun, Levy, Oren A., Young-Pearse, Tracy L., Selkoe, Dennis, Dettmer, Ulf
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789936/
https://ncbi.nlm.nih.gov/pubmed/31548371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903216116
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