The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle

Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain d-serine production, but this hypothesis remains untested. We now report that inh...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Neame, Samah, Safory, Hazem, Radzishevsky, Inna, Touitou, Ayelet, Marchesani, Francesco, Marchetti, Marialaura, Kellner, Shai, Berlin, Shai, Foltyn, Veronika N., Engelender, Simone, Billard, Jean-Marie, Wolosker, Herman
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789919/
https://ncbi.nlm.nih.gov/pubmed/31548413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909458116
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