Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production: IMPLICATIONS FOR N-METHYL-d-ASPARTATE (NMDA) RECEPTOR ACTIVATION

d-Serine is a physiological co-agonist that activates N-methyl d-aspartate receptors (NMDARs) and is essential for neurotransmission, synaptic plasticity, and behavior. d-Serine may also trigger NMDAR-mediated neurotoxicity, and its dysregulation may play a role in neurodegeneration. d-Serine is syn...

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Vydáno v:J Biol Chem
Hlavní autoři: Kolodney, Goren, Dumin, Elena, Safory, Hazem, Rosenberg, Dina, Mori, Hisashi, Radzishevisky, Inna, Wolosker, Herman
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692229/
https://ncbi.nlm.nih.gov/pubmed/26553873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699496
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