The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and sp...

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Gepubliceerd in:EMBO Rep
Hoofdauteurs: Safory, Hazem, Neame, Samah, Shulman, Yoav, Zubedat, Salman, Radzishevsky, Inna, Rosenberg, Dina, Sason, Hagit, Engelender, Simone, Avital, Avi, Hülsmann, Swen, Schiller, Jackie, Wolosker, Herman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2015
Onderwerpen:
Scientific Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428048/
https://ncbi.nlm.nih.gov/pubmed/25755256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439561
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