ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment

d-serine is a physiologic coagonist of NMDA receptors, but little is known about the regulation of its synthesis and synaptic turnover. The amino acid exchangers ASCT1 (Slc1a4) and ASCT2 (Slc1a5) are candidates for regulating d-serine levels. Using ASCT1 and ASCT2 KO mice, we report that ASCT1, rath...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kaplan, Eitan, Zubedat, Salman, Radzishevsky, Inna, Valenta, Alec C., Rechnitz, Ohad, Sason, Hagit, Sajrawi, Clara, Bodner, Oded, Konno, Kohtarou, Esaki, Kayoko, Derdikman, Dori, Yoshikawa, Takeo, Watanabe, Masahiko, Kennedy, Robert T., Billard, Jean-Marie, Avital, Avi, Wolosker, Herman
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156681/
https://ncbi.nlm.nih.gov/pubmed/30185558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722677115
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